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Meta-Analysis of Proportions and Pooled Prevalence

Pool prevalence, incidence or single-arm proportions across studies. Get the pooled proportion with its 95% CI and prediction interval, heterogeneity statistics and a forest plot.

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Transformation
Model
StudyEvents (cases)Sample size
StudyProportion, % (95% CI)Estimate [95% CI]WeightGiannotta et al. (16/17)94.1 [68.0, 99.2]4.1%Haraguchi & Ebina (10/12)83.3 [52.3, 95.8]6.0%Swift & Solomon (4/8)50.0 [20.0, 80.0]6.7%Kassell et al. (43/58)74.1 [61.4, 83.8]12.9%Tanabe et al. (10/10)95.5 [55.2, 99.7]2.4%Awad et al. (25/42)59.5 [44.3, 73.1]12.6%Finn et al. (13/14)92.9 [63.0, 99.0]4.0%Hadeishi et al. (12/12)96.2 [59.7, 99.8]2.4%Otsubo et al. (22/41)53.7 [38.5, 68.1]12.6%Muizelaar & Becker (4/5)80.0 [30.9, 97.3]3.6%Rosenstein et al. (5/6)83.3 [36.9, 97.7]3.7%Levy et al. (18/23)78.3 [57.2, 90.7]9.4%Shimoda et al. (58/68)85.3 [74.8, 91.9]12.1%Solomon et al. (6/10)60.0 [29.7, 84.2]7.5%Random-effects model75.7 [66.1, 83.3]100%20406080100I² = 56%, τ² = 0.362, Q = 29.79 (df = 13, p = 0.005)- - 95% prediction interval

Results (14 studies, random effects)

Pooled proportion75.7% (95% CI 66.1% to 83.3%)
95% prediction interval43.2% to 92.8%Where the proportion in a new setting is likely to lie
I²56.4%may represent substantial heterogeneity (50-90%)
Cochran's Q29.79 (df = 13, p = 0.005)
τ²0.3616On the logit scale
Total participants326
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How to Use the Meta-Analysis of Proportions

  1. 1

    Enter each study

    Number of events (cases) and the sample size.

  2. 2

    Choose the transformation

    Logit is recommended; Freeman-Tukey is also available.

  3. 3

    Read the pooled prevalence

    With CI, prediction interval, I² and forest plot.

How to pool proportions in a meta-analysis

Proportions are transformed before pooling so that their sampling distribution is closer to normal and their variance does not depend on the proportion itself. The pooled value is then back-transformed to a percentage.

The logit transformation is widely used. The Freeman-Tukey double arcsine transformation handles proportions of 0% and 100% smoothly, but its back-transformation can give misleading pooled values when study sizes differ greatly (Schwarzer et al. 2019).

Prevalence meta-analyses usually show high heterogeneity, so the prediction interval is often more informative than the confidence interval.

How it is calculated

Sources

Meta-Analysis of Proportions: FAQ

Logit or Freeman-Tukey: which should I use?

Logit is a safe default. If you use Freeman-Tukey, check the back-transformed result against the logit analysis, especially when study sizes vary a lot.

Why is I² so high in prevalence meta-analyses?

Large studies give very precise proportions, so even small real differences between settings produce high I². Report the prediction interval and explore sources of heterogeneity.

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